STANDARDIZATION OF BOTULISM ANTITOXINS

The Dose of Antitoxins

? columns the tendency to draw far reaching conclusions on inadequate grounds purporting to be based on experimental data, I take the opportunity offered by Major Carr-Whiteis interesting paper " Is Antivenene of any value in Cobra Poisoning, in your current number to again draw attention to this important matter in relation to the anti-toxins, taking for illustration anti-venene, anti-tet ino-...

[Botulism].

Botulism is a rare but serious paralytic illness caused by a nerve toxin that is produced by the bacterium Clostridium botulinum and sometimes by strains of Clostridium butyricum and Clostridium baratii. There are three main forms of botulism: foodborne botulism, caused by eating foods containing the botulinum toxin; wound botulism, caused by toxin produced in a wound infected with C. botulinum...

Toxins and Antitoxins of Bacillus Dysenteriæ Shiga

With the methods which have been described we have separated an exotoxin and an endotoxin from cultures of the Shiga dysenteric bacillus. The study of the nature and effect of the poison of this microorganism is thus simplified. The two toxins are physically and biologically distinct. The exotoxin is relatively heat-labile, arises in the early period of growth, and yields an antiexotoxic immune...

Preparation of standard Clostridial antitoxins in sheep

[Human botulism immuneglobulin for the treatment of infant botulism].

BACKGROUND We created the orphan drug Human Botulism Immune Globulin Intravenous (Human) (BIG-IV), which neutralizes botulinum toxin, and evaluated its safety and efficacy in treating infant botulism, the intestinal-toxemia form of human botulism. METHODS We performed a five-year, randomized, double-blind, placebo-controlled trial statewide, in California, of BIG-IV in 122 infants with suspec...